Семью Симпсонов озвучивают:

Homer J. Simpson - Dan Castellaneta
Marjorie "Marge" Simpson - Julie Kavner
Bartholomew "Bart" Jo-Jo Simpson - Nancy Cartwright
Lisa Marie Simpson - Yeardley Smith
Margaret "Maggie" Simpson (посасывание соски) - Matt Groening
Margaret "Maggie" Simpson (в одноим из эпизодов) - Elizabeth Taylor
Margaret "Maggie" Simpson (в одном из эпизодов) - James Earl Jones
Santa's Little Helper - Frank Welker и Dan Castellaneta

Другие роли озвучивали
(полный список):

Agnes Skinner - Tress MacNeille
Apu Nahasapeemapetilon - Hank Azaria
Arnie Pie - Dan Castellaneta
Artie Ziff - Jon Lovitz
Barney Gumble - Dan Castellaneta
Bleeding Gums Murphy - Ron Taylor
Bumblebee Man - Hank Azaria
Captain McAllister - Harry Shearer
Carl Carlson - Hank Azaria
Chief Clancy Wiggum - Hank Azaria
Cletus the slack-jawed yokel - Hank Azaria
Comic Book Guy - Hank Azaria
Dave Sutton - Harry Shearer
Disco Stu - Dan Castellaneta
Dolph - Pamela Hayden
Dr. Julius Hibbert - Harry Shearer
Dr. Marvin Monroe - Harry Shearer
Dr. Nick Riviera - Hank Azaria
Dr. Pryor - Harry Shearer
Eddie - Harry Shearer
Fat Tony - Joe Mantegna
Gil - Hank Azaria
Grandma Jacqueline Bouvier - Julie Kavner
Grandma Mona Simpson - Glenn Close
Grampa Abraham J. Simpson - Dan Castellaneta
Groundskeeper Willie - Dan Castellaneta
Hans Moleman - Dan Castellaneta
Helen Lovejoy - Maggie Roswell
Herbert Powell - Danny DeVito
Herman - Harry Shearer
Itchy the mouse - Dan Castellaneta
Janey Powell - Pamela Hayden
Jasper - Harry Shearer
Jebediah Obadiah Zacharia Jedediah Springfield - Harry Shearer
Jimbo Jones - Pamela Hayden
Kang - Harry Shearer
Kearney - Nancy Cartwright
Kent Brockman - Harry Shearer
Kirk Van Houten - Hank Azaria
Kodos - Dan Castellaneta
Krusty the Clown (Herschel Krustofsky) - Dan Castellaneta
Legs - Hank Azaria
Lenny - Harry Shearer
Lewis Wendell - Russi Taylor
Lionel Hutz - Phil Hartman
Lou - Hank Azaria
Louie - Harry Shearer
Luanne Van Houten - Maggie Roswell
Lunchlady Doris - Doris Grau
Manjula Nahasapeemapetilon - Jan Hooks
Manjula Nahasapeemapetilon - Tress MacNeille
Martin Prince - Russi Taylor
Maude Flanders - Maggie Roswell
Mayor Diamond Joe Quimby - Dan Castellaneta
Milhouse Van Houten - Pamela Hayden
Miss Albright - Tress MacNeille
Miss Edna Krabappel - Marcia Wallace
Miss Elizabeth Hoover - Maggie Roswell
Moe Szyslak - Christopher Collins (1990-92 гг.)
Moe Szyslak - Hank Azaria (1992-по сей день)
Mr. Charles Montgomery Burns - Christopher Collins (1990-92 гг.)
Mr. Charles Montgomery Burns - Harry Shearer (1992-по сей день)
Mr. Dewey Largo - Harry Shearer
Mrs. Glick - Tress MacNeille
Mrs. Sarah Wiggum - Nancy Cartwright
Ned Flanders - Harry Shearer
Nelson Muntz - Nancy Cartwright
Otto Mann - Harry Shearer
Patty Bouvier - Julie Kavner
Pimple-faced teenagers - Hank Azaria
Principal Seymour Skinner - Harry Shearer
Professor John Frink - Hank Azaria
Rainier Wolfcastle ("McBain") - Harry Shearer
Ralph Wiggum - Nancy Cartwright
Reverend Timothy Lovejoy - Harry Shearer
Rod Flanders - Nancy Cartwright
Roger Myers - Alex Rocco
Scratchy the cat - Harry Shearer
Selma Bouvier - Julie Kavner
Sherri - Russi Taylor
Sideshow Bob (Robert Underdunk Terwilliger) - Kelsey Grammer
Sideshow Mel (Melvin Van Horne) - Dan Castellaneta
Snake - Hank Azaria
Superintendent Chalmers - Hank Azaria
Terri - Russi Taylor
Todd Flanders - Nancy Cartwright
Troy McClure - Phil Hartman
Uter - Russi Taylor
Waylon J. Smithers - Harry Shearer